Are Th17 cells an appropriate new target in the treatment of rheumatoid arthritis?

نویسندگان

  • Hiroshi Kato
  • David A Fox
چکیده

Th17 cells play crucial roles not only in host defense but also in many human autoimmune diseases and corresponding animal models. Although many of the fundamental principles regarding Th17 biology have been rapidly elucidated in mice, there remain numerous controversies regarding the differentiation, plasticity, and pathogenicity of human Th17 cells. In this review, we consider these open questions in comparison to what has already been clarified in mice, and discuss the potential impact of discoveries related to the Th17 pathway on the development of new therapeutic strategies in Th17 driven autoimmune diseases, specifically rheumatoid arthritis.

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عنوان ژورنال:
  • Clinical and translational science

دوره 3 6  شماره 

صفحات  -

تاریخ انتشار 2010